{"id":800,"date":"2022-07-31T10:22:31","date_gmt":"2022-07-31T15:22:31","guid":{"rendered":"https:\/\/pages.stolaf.edu\/colee\/?page_id=800"},"modified":"2024-08-01T12:28:07","modified_gmt":"2024-08-01T17:28:07","slug":"organelle-18","status":"publish","type":"page","link":"https:\/\/pages.stolaf.edu\/colee\/750-2\/organelle-18\/","title":{"rendered":"Early Endosome"},"content":{"rendered":"\n<p>In Tetrahymena, Early Endosomes serve a crucial role in endocytosis as the sorter of internalized proteins and lipids retrieved from the extracellular environment. Once inside the Early Endosome, these resources are separated into distinct areas of the endosome where they will be sent to different parts of the cell for various purposes. For Tetrahymena, coated vesicles from Parasomal sacs are also known to fuse with the Early Endosomes to deliver nutrients.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Articles:<\/h2>\n\n\n\n<p><a href=\"https:\/\/www.molbiolcell.org\/doi\/full\/10.1091\/mbc.E22-11-0501\">Cole, E. S., Maier, W., Joachimiak, E., Jiang, Y. Y., Lee, C., Collet, E., &#8230; &amp; Gaertig, J. (2023). The Tetrahymena bcd1 mutant implicates endosome trafficking in ciliate, cortical pattern formation.&nbsp;<em>Molecular biology of the cell<\/em>,&nbsp;<em>34<\/em>(8), ar82.<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2810677\/\">Jovic, M., Sharma, M., Rahajeng, J., &amp; Caplan, S. (2010). The early endosome: a busy sorting station for proteins at the crossroads.&nbsp;<em>Histology and histopathology<\/em>,&nbsp;<em>25<\/em>(1), 99\u2013112.<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Media:<\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"608\" src=\"https:\/\/pages.stolaf.edu\/colee\/wp-content\/uploads\/sites\/901\/2024\/06\/Biogenesis_of_exosomes-1024x608.jpg\" alt=\"\" class=\"wp-image-1301\" srcset=\"https:\/\/pages.stolaf.edu\/colee\/wp-content\/uploads\/sites\/901\/2024\/06\/Biogenesis_of_exosomes-1024x608.jpg 1024w, https:\/\/pages.stolaf.edu\/colee\/wp-content\/uploads\/sites\/901\/2024\/06\/Biogenesis_of_exosomes-300x178.jpg 300w, https:\/\/pages.stolaf.edu\/colee\/wp-content\/uploads\/sites\/901\/2024\/06\/Biogenesis_of_exosomes-150x89.jpg 150w, https:\/\/pages.stolaf.edu\/colee\/wp-content\/uploads\/sites\/901\/2024\/06\/Biogenesis_of_exosomes-768x456.jpg 768w, https:\/\/pages.stolaf.edu\/colee\/wp-content\/uploads\/sites\/901\/2024\/06\/Biogenesis_of_exosomes.jpg 1390w\" sizes=\"auto, (max-width: 706px) 89vw, (max-width: 767px) 82vw, 740px\" \/><\/figure>\n\n\n\n<p>Image illustrates the biogenesis of exosomes and the inward budding of early endosomes to form vesicles to carry proteins and RNA. Credited to Law ZJ, Khoo XH, Lim PT, Goh BH, Ming LC, Lee WL and Goh HP under the&nbsp;<a href=\"https:\/\/en.wikipedia.org\/wiki\/en:Creative_Commons\">Creative Commons<\/a>&nbsp;<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.en\">Attribution 4.0 International<\/a>&nbsp;license.<\/p>\n\n\n\n<style>\n\t#hotspot-1164 .hotspots-image-container,\n\t#hotspot-1164 .leaflet-container {\n\t\tbackground: #efefef\t}\n\n\t#hotspot-1164 .hotspots-placeholder,\n\t.featherlight .featherlight-content.lightbox-1164 {\n\t\tbackground: #ffffff;\n\t\tborder: 0 #ffffff solid;\n\t\tcolor: #000000;\n\t}\n\n\t#hotspot-1164 .hotspot-title,\n\t#hotspot-1164 .bc-product__title a,\n\t.featherlight .featherlight-content.lightbox-1164 .hotspot-title,\n\t.featherlight .featherlight-content.lightbox-1164 .bc-product__title a {\n\t\tcolor: #000000;\n\t}\n\n\t\t\t#hotspot-1164 .hotspot-style-1 {\n\t\t\tstroke-width: 1;\n\t\t\tfill: #ffffff;\n\t\t\tfill-opacity: 0.01;\n\t\t\tstroke: 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Vesicle\"\n\t\t\t\t\tdata-action=\"url\"\n\t\t\t\t\tdata-color-scheme=\"style-1\"\n\t\t\t\t\tdata-id=\"area-hotspot-1164-8\"\n\t\t\t\t\ttarget=\"\"\n\t\t\t\t\tclass=\"url-area\"\n\t\t\t\t\t>\n\t\t\t\t\t\t\t\t\t\t\t<area\n\t\t\t\t\tshape=\"circle\"\n\t\t\t\t\tcoords=\"335,213,8\"\n\t\t\t\t\thref=\"https:\/\/pages.stolaf.edu\/colee\/750-2\/organelle-14\/\"\n\t\t\t\t\trel=\"\"\n\t\t\t\t\ttitle=\"Coasted Vesicle\"\n\t\t\t\t\talt=\"Coasted Vesicle\"\n\t\t\t\t\tdata-action=\"url\"\n\t\t\t\t\tdata-color-scheme=\"style-1\"\n\t\t\t\t\tdata-id=\"area-hotspot-1164-9\"\n\t\t\t\t\ttarget=\"\"\n\t\t\t\t\tclass=\"url-area\"\n\t\t\t\t\t>\n\t\t\t\t\t\t\t\t\t\t\t<area\n\t\t\t\t\tshape=\"circle\"\n\t\t\t\t\tcoords=\"334,245,8\"\n\t\t\t\t\thref=\"https:\/\/pages.stolaf.edu\/colee\/750-2\/organelle-14\/\"\n\t\t\t\t\trel=\"\"\n\t\t\t\t\ttitle=\"Coasted Vesicle\"\n\t\t\t\t\talt=\"Coasted Vesicle\"\n\t\t\t\t\tdata-action=\"url\"\n\t\t\t\t\tdata-color-scheme=\"style-1\"\n\t\t\t\t\tdata-id=\"area-hotspot-1164-10\"\n\t\t\t\t\ttarget=\"\"\n\t\t\t\t\tclass=\"url-area\"\n\t\t\t\t\t>\n\t\t\t\t\t\t\t\t\t\t\t<area\n\t\t\t\t\tshape=\"circle\"\n\t\t\t\t\tcoords=\"406,485,8\"\n\t\t\t\t\thref=\"https:\/\/pages.stolaf.edu\/colee\/750-2\/organelle-14\/\"\n\t\t\t\t\trel=\"\"\n\t\t\t\t\ttitle=\"Coasted Vesicle\"\n\t\t\t\t\talt=\"Coasted Vesicle\"\n\t\t\t\t\tdata-action=\"url\"\n\t\t\t\t\tdata-color-scheme=\"style-1\"\n\t\t\t\t\tdata-id=\"area-hotspot-1164-11\"\n\t\t\t\t\ttarget=\"\"\n\t\t\t\t\tclass=\"url-area\"\n\t\t\t\t\t>\n\t\t\t\t\t\t\t\t\t\t\t<area\n\t\t\t\t\tshape=\"circle\"\n\t\t\t\t\tcoords=\"427,232,10\"\n\t\t\t\t\thref=\"https:\/\/pages.stolaf.edu\/colee\/750-2\/organelle-14\/\"\n\t\t\t\t\trel=\"\"\n\t\t\t\t\ttitle=\"Coated Vesicle\"\n\t\t\t\t\talt=\"Coated Vesicle\"\n\t\t\t\t\tdata-action=\"url\"\n\t\t\t\t\tdata-color-scheme=\"style-1\"\n\t\t\t\t\tdata-id=\"area-hotspot-1164-12\"\n\t\t\t\t\ttarget=\"\"\n\t\t\t\t\tclass=\"url-area\"\n\t\t\t\t\t>\n\t\t\t\t\t<\/map>\n\n\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t<div class=\"hotspot-info \" id=\"hotspot-hotspot-1164-0\">\n\t\t\t\t\n\t\t\t\t<h2 class=\"hotspot-title\">Early Endosome<\/h2>\t\t\t\t\t\t\t\t<div class=\"hotspot-content\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\n\t\t\t\t\t\t<div class=\"hotspot-info \" id=\"hotspot-hotspot-1164-1\">\n\t\t\t\t\n\t\t\t\t<h2 class=\"hotspot-title\">Early Endosome<\/h2>\t\t\t\t\t\t\t\t<div class=\"hotspot-content\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\n\t\t\t\t\t\t<div class=\"hotspot-info \" id=\"hotspot-hotspot-1164-2\">\n\t\t\t\t\n\t\t\t\t<h2 class=\"hotspot-title\">Early Endosome<\/h2>\t\t\t\t\t\t\t\t<div class=\"hotspot-content\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\n\n\n\n<p><a href=\"https:\/\/www6.pbrc.hawaii.edu\/allen\/ch18\/\"><\/a>Image depicts the cross section of a Tetrahymena cell and the cell structures of interest within it. <a href=\"https:\/\/www6.pbrc.hawaii.edu\/allen\/ch18\/\">Credited to Professor Richard Allen and his Image Collection, permission to use image collection granted by Hawaii University<\/a>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Genes, Proteins, and Mutations:<\/h2>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In Tetrahymena, Early Endosomes serve a crucial role in endocytosis as the sorter of internalized proteins and lipids retrieved from the extracellular environment. Once inside the Early Endosome, these resources are separated into distinct areas of the endosome where they will be sent to different parts of the cell for various purposes. For Tetrahymena, coated &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/pages.stolaf.edu\/colee\/750-2\/organelle-18\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Early Endosome&#8221;<\/span><\/a><\/p>\n","protected":false},"author":4491,"featured_media":0,"parent":750,"menu_order":17,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-800","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pages.stolaf.edu\/colee\/wp-json\/wp\/v2\/pages\/800","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pages.stolaf.edu\/colee\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pages.stolaf.edu\/colee\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pages.stolaf.edu\/colee\/wp-json\/wp\/v2\/users\/4491"}],"replies":[{"embeddable":true,"href":"https:\/\/pages.stolaf.edu\/colee\/wp-json\/wp\/v2\/comments?post=800"}],"version-history":[{"count":21,"href":"https:\/\/pages.stolaf.edu\/colee\/wp-json\/wp\/v2\/pages\/800\/revisions"}],"predecessor-version":[{"id":2936,"href":"https:\/\/pages.stolaf.edu\/colee\/wp-json\/wp\/v2\/pages\/800\/revisions\/2936"}],"up":[{"embeddable":true,"href":"https:\/\/pages.stolaf.edu\/colee\/wp-json\/wp\/v2\/pages\/750"}],"wp:attachment":[{"href":"https:\/\/pages.stolaf.edu\/colee\/wp-json\/wp\/v2\/media?parent=800"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}